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ea0032oc6.4 | Diabetes & Obesity | ECE2013

Reduction of fat mass with the mTOR inhibitor, sirolimus, in humans: from transplantation to lipodystrophies

Parent Emilie , Pattou Francois , Ernst Olivier , Lion Georges , Wolowczuk Isabelle , Dharancy Olivier , Noel Christian , Kerr-Conte Julie , Vantyghem Marie-Christine

Objectives: Sirolimus inhibits adipocyte differentiation (Yeh PNAS 1995). This study compares weight and fat markers in two groups of patients treated or not with sirolimus, before and after transplantation.Patients and method: Nineteen islet-alone transplanted patients treated with sirolimus and 7 islet-alone or liver-transplanted patients NOT treated with sirolimus were compared 1 year after transplantation in terms of weight, fat mass (equation of bod...

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ea0035oc11.5 | Diabetes and Obesity 2 | ECE2014

Lipodystophic laminopathies are characterised by an increased intra/whole abdominal fat ratio with preserved fat/lean mass ratio and hypoleptinemia, in contrast with obese people, compared to controls

Le Mapihan Kristell , Leroy Clara , Ernst Olivier , Vigouroux Corinne , Lion Georges , Le Guillou Anne-Claire , Quintin Delphine , Douillard Claire , Vantyghem Marie-Christine

Introduction: The diagnosis of non-HIV lipodystrophies is challenging, especially since borderline forms with type 2 diabetes have been described (Strickland Diabetes Care 2013).Objective: To identify the most specific anthropometric and biological parameters enabling to differentiate lipodystrophic from obese and control subjects.Methods: This prospective study (clin.gov 2009-AO-1169-48) included 94 patients divided in 3 groups ad...

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Endocrine Abstracts

Reduction of fat mass with the mTOR inhibitor, sirolimus, in humans: from transplantation to lipodystrophies

Lipodystophic laminopathies are characterised by an increased intra/whole abdominal fat ratio with preserved fat/lean mass ratio and hypoleptinemia, in contrast with obese people, compared to controls

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